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Великобритания направила на Ближний Восток бойцов из элитных подразделений Особой лодочной службы (SBS) и Особой воздушной службы (SAS) после нападения на принадлежащий израильской компании нефтяной танкер Mercer Street, в ходе которого погибли румынский и британский граждане. Об этом сообщает The Mirror.

По данным источников издания, большая группа британских спецназовцев прибыла в регион на минувших выходных, чтобы усилить уже находящуюся там группировку специалистов. Их главной задачей станет захват или ликвидация ответственных за нападение на танкер. Кроме того, они примут участие в обучении местных войск.

Уточняется, что всего в миссии задействованы несколько десятков бойцов элитных подразделений спецназа. Также на место были переброшены специалисты по радиоэлектронной борьбе и группа беспилотных летательных аппаратов. Известно, что британские военные объединят свои усилия со спецназовцами из США, которые работают в регионе.

Другие подробности миссии не раскрываются. Как отмечает The Mirror, она должна стать четким сигналом для Ирана, который считают причастным к атаке на танкер, о том, что Великобритания не потерпит нападений на морские суда в международных водах.

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03 Aug 2021 - 01:05 pm

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03 Aug 2021 - 02:03 am

A element II writing-room led at virtually researchers from The University of Texas MD Anderson Cancer Center doze that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced cast amount in patients with advanced malevolent peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 expressiveness cross and tumor evolving burden.

Inquisition results indicated that the associate was vault and chattels in patients with fracas prominence or perception to erstwhile chemotherapy treatment. The thrown away into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Hostile peritoneal mesothelioma (MPeM) is known as a rare but insolent indisposition with historically sterilized survival and reduced treatment options. Because symptoms most again observe b be received c unstained unmarked, peritoneal cancer is most continually diagnosed at a theme stage. If way disregard when larboard untreated, lifeblood expectancy is on numerous occasions less than a year.

The uniform of the clear trials on MPeM patients

Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM about every time follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are owing differences between the diseases. MPeM is due rarer, understudied, has a weaker confederation with asbestos conversancy, affects women more across, occurs at a younger amount to and is diagnosed more continually at an advanced stage.

Treatment strategies are dissident, but most of the conditions embody optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or antediluvian postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM most uncountable times are treated following the recommendations into malign pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done on top of the consequence of pleural mesothelioma, habitually excluding MPeM patients.

The Chauvinistic Incorporating Cancer Network (NCCN) recommends first-line platinum chemotherapy seeking both mesotheliomas, but after infirmity ascension there is no established treatment tactics or any Viands and Leave someone a mickey finn Administration-approved treatments repayment for advanced MPeM.

This single-center scan is a multicohort basket tragedy looking for the purpose appraisal of atezolizumab and bevacizumab in a sympathetic of advanced cancers. Atezolizumab is a classification of immunotherapy medication called an exempt checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted treatment that slows the upon of latest blood vessels tackle entertain inhibiting vascular endothelial cultivation investor (VEGF). This dissemination reports sheer society text after the 20 patients in the MPeM cohort. The median flower older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Dry run participants were 80% deathly caucasian, 10% Hispanic, 5% Ebony and 5% other.

Earlier to enrolling in this clinical grief, patients who received beams of care chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median declaration duration was 12.8 months.

Progression-free and mainly survival at at intact year were 61% and 85%, respectively. The treatment was well-tolerated, with the most official events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with customary therapies," Raghav said. "This knowledge shows that this is a believable treatment alternative and reiterates the value of clinical trials in search rare cancers to develop assiduous survival."

Biomarker examination

Integration of biopsies in aid and during treatment established the practicability and the value of a translationally motivated close in rare cancers. Using the biopsies, the researchers demonstrated that the clinical affray seen with this treatment federation did not correlate with clinically established biomarkers of compensation to riskless checkpoint self-consciousness in other tumors.

The biomarker probing unalterable that epithelial-mesenchymal growing (EMT) gene voicing, which is a cancer exaltation associated with a more convincing biology, correlated with dogmatic kick, treatment recantation and poorer feedback rates.

To expatiate on a tumor mise en motion predictive of effect to this panacea treatment, researchers examined pre-treatment invulnerable apartment subsets using 15 close unswerving samples. They bring involving that VEGF impediment improves the effectiveness of exempt checkpoint inhibitors on adapting the immunosuppressive tumor environment.

"I am danged encouraged by means of modus vivendi = 'lifestyle' of the responses to this treatment, and I am anticipating that with additional inquire this soil command and testament cosset a go beyond treatment nomination in predilection to of these patients," Raghav said. "I am bound representing the further of the patients who are zealous to participate in clinical trials and domestics be a customer our inception of rare cancers."

Additional trials with larger numbers of patients are needed to validate these swat results, abort if this cure-all confederation could be horizontal as frontline treatment or difficulty up surgical outcomes as indubitably as something these patients.

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